Apparently, X Files will be shot in Vancouver, with the original studio. Also, William B Davis is back. Obviously, The Smoking Man can't die...
YES! The Smoking Man WILL return. The show will be shot in Vancouver and the original studio has been secured. William has been asked to clear his schedule for the summer! ~ Rachel

Update:
Local actor William B. Davis, who portrayed the shadowy “Smoking Man,”
confirmed the show’s newly-announced six-episode run will be shot where
the series began over two decades ago. “That’s my understanding and I actually have my understanding from the
horse’s mouth,” Davis said. “It will actually shoot here in Vancouver,
and soon – starting in June.”
That’s in spite of the fact “The Smoking Man” has already died three times. “As they say, no one ever dies on ‘The X-Files,’” Davis said. “What
they’re going to do in term of regenerating my character, I don’t know.
I’m as excited to see that as anyone.”
Check his video on this link: CTV News